Olivia Breen, 26, upgraded the Commonwealth she bronze in the women’s T38 100m four years ago as she stunned England’s reigning champion Sophie Hahn.
“I can’t describe how I’m feeling, this morning I knew I was in good shape,” Olivia Breen said.
“My preparation has been good. I ran a big personal best two weeks ago, so I wanted to repeat that.
“It was a good start, [I told myself to] keep going and get to the line. It was an amazing atmosphere. It’s so lovely to have the crowd again and normal life again.
“All my family and friends are here, who have been with me throughout the journey.”
Breen admitted the victory justified all the hard work.
“I am getting emotional, it has been 10 years of hard work and I have never run this fast, I am just so happy!
“I’ve just kept going. I’ve had days where I thought ‘why am I doing this?’ we all have them, but you just have to keep going, it will come eventually.
“Sophie has obviously been a main rival for years, but I just kept saying ‘Olivia, you can do this, it will come’, and it has come!”
Welsh sprinters Jeremiah Azu, Hannah Brier and Olivia Breen advanced from their heats as the track and field got under way in Birmingham.
Azu, in his first race since winning the British title, eased through his men’s 100m heat in 10.35 seconds.
Welsh record holder Brier ran 11.48 seconds to go through as one of three fastest losers in the women’s 100m.
Both will race in their respective semi-finals on Wednesday night.
“The race was good,” Azu told BBC Sport Wales.
“It’s nice to be back running fast. The crowd here is amazing – they made so much noise.
“So I’m looking forward to tomorrow. Come back, do the business, get in that final and hopefully leave with a medal.”
UK shot put champion Adele Nicoll made her Commonwealth Games debut, throwing 17.30m to advance to Wednesday night’s final.